Dynamic evolutionary characteristics and influence mechanisms of carbon emission intensity in counties of the Yangtze River Delta, China.

Clarifying the intrinsic mechanism of county carbon emission intensity (CEI) is essential for guiding the realization of a low-carbon economy as well as for the strategic goals of carbon peaking and carbon neutrality. However, at present, scholars mostly focus on provincial and city scales, with the identification of influencing factors and spatial effect mechanisms of CEI rarely included in the analysis framework. Herein, with the help of three spatial weight matrices, the spatial autocorrelation, the "F + S" influence factor identification method, and the spatial panel econometric model were used to analyze the evolutionary paths and influencing factors of CEI for 209 counties in the Yangtze River Delta (YRD) from 2007 to 2020. The results show that (1) the CEI of the YRD decreased from 1.998t/104 RMB to 0.858t/104 RMB. Furthermore, the spatial pattern was low in the southeast and high in the northwest, with high-value areas concentrated in municipal districts and resource-based counties. (2) Moran's I spatial autocorrelation index indicated significant spatial clustering of county CEI. (3) Financial science and technology expenditure, industrial structure, share of urban built-up land, and the urban-rural income gap affected the change in CEI and its spatial effect, whereas total imports and exports had a significant negative effect on local CEI. Therefore, to achieve China's "double carbon" goal, it is necessary to consider the five development concepts as the core, strengthen inter-county exchanges and collaboration, as well as promote collaborative management of the ecological environment.

Spatial correlation and coupling between industrial enterprise agglomeration and water pollutant discharge.

Industrial wastewater discharge has become the main cause of water pollution in China. However, the spatial interaction mechanism between industrial structure and water pollution is still unclear. Accordingly, we evaluated and analyzed spatiotemporal changes of the agglomeration pattern of pollution-intensive industrial enterprises and the evolution of the water environmental pollution pattern, as well as the correlation between them. The study results show that the polluting industrial enterprises were located mainly along the Yangtze River and Taihu Lake Basin in southern Jiangsu in 2013 and 2018. However, we observed a spatial trend of pollution transfer to northern Jiangsu. The industrial water pollution discharge presents the distribution pattern of facing rivers, seas, lakes and cities. Papermaking and paper products industry are the leading factors of COD and NH3-N pollution, with explanatory power of 0.3666 and 0.6201 respectively. The spatial positive coupling effect between the concentration degree of polluting enterprises and the intensity of water environment pollution discharge is 94.95% of the region. The spatial agglomeration of polluting industrial enterprises is an important cause of water environment pollution. They promote and couple each other, proving the existence of "Pollution haven" and "Porter hypothesis".

Coordinated Evolution and Influencing Factors of Population and Economy in the Yangtze River Economic Belt.

The degree of population-economy coupling and coordination is an important indicator of a region's balanced development. This study examines the evolution of the population-economy coupling coordination pattern in the Yangtze River Economic Belt spanning from 2000 to 2019. It draws from the economic growth stage and related theories, and employs methods such as geographic concentration, center of gravity analysis, and the coupling coordination model. Accordingly, the population and economy of the Yangtze River Economic Belt form a core-periphery, with a decreasing center toward the periphery, and the east higher than the west. The spatial coupling situation of the population-economic center of gravity yields an inverted U-shaped curve, where their center of gravity separates and then converges, and the difference in regional development expands and then shrinks. Moreover, the population center of gravity lags behind that of the economy. The population-economy coupling and coordination degree shows a decreasing trend after rising fluctuations. Further, the study finds that regional economic development, government role, and market-led capital agglomeration are significant drivers of the population-economy coupling and coordination, with the industrial structural influence being spatially heterogeneous.

Palbociclib regulates the expression of dihydrofolate reductase and the cell cycle to inhibit t (11;14) multiple myeloma.

Background: Multiple myeloma (MM) with t (11;14) has a unique biology. New combinations of novel agents are needed to improve the prognosis of patients with t (11;14) MM. As a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), palbociclib (PAL) has been used to treat various malignancies, including breast cancer, ovarian cancer, and so on. However, the effects of PAL on MM remain unclear, and thus, further investigations are warranted. Methods: Two t (11;14) MM cell lines, U266 and KMS27, were used in this study. The cell viability and cell cycle were detected to evaluate the anti-myeloma effect of the combination of pralatrexate (PTX) and methotrexate (MTX) with PAL. Three-dimensional (3D) spheroid and mouse models were built to verify the effect of the combination treatment. Western blot was used to detect the expressions of Minichromosome Maintenance Complex Component 2 (MCM2), Minichromosome Maintenance Complex Component 3 (MCM3), and dihydrofolate reductase (DHFR). Results: It was observed that PAL had obvious anticancer effects on U266 and KMS27 cells, which had synergistic effects together with PTX and MTX. Importantly, it was found that PAL could promote cell cycle genes including MCM2 and MCM3, and increase the number of MM cells in the G1 phase. Moreover, PAL reduced the expression level of DHFR and exerted its anticancer effects on MM cells by targeting DHFR. It was also determined that PAL exerted anticancer effects on MM in the spheroid and mouse models. Conclusions: PAL exerted obvious anticancer effects on t (11;14) MM cells, which had synergistic effects together with PTX and MTX. PAL could promote cell cycle genes and the G1 phase of MM cells. Moreover, PAL reduced the expression level of DHFR and exerted its anticancer effects on t (11;14) MM cells by targeting DHFR.

Responses of soil greenhouse gas emissions to land use conversion and reversion-A global meta-analysis.

Exploring the responses of greenhouse gas (GHG) emissions to land use conversion or reversion is significant for taking effective land use measures to alleviate global warming. A global meta-analysis was conducted to analyze the responses of carbon dioxide (CO2 ), methane (CH4 ), and nitrous oxide (N2 O) emissions to land use conversion or reversion, and determine their temporal evolution, driving factors, and potential mechanisms. Our results showed that CH4 and N2 O responded positively to land use conversion while CO2 responded negatively to the changes from natural herb and secondary forest to plantation. By comparison, CH4 responded negatively to land use reversion and N2 O also showed negative response to the reversion from agricultural land to forest. The conversion of land use weakened the function of natural forest and grassland as CH4 sink and the artificial nitrogen (N) addition for plantation increased N source for N2 O release from soil, while the reversion of land use could alleviate them to some degree. Besides, soil carbon would impact CO2 emission for a long time after land use conversion, and secondary forest reached the CH4 uptake level similar to that of primary forest after over 40 years. N2 O responses had negative relationships with time interval under the conversions from forest to plantation, secondary forest, and pasture. In addition, meta-regression indicated that CH4 had correlations with several environmental variables, and carbon-nitrogen ratio had contrary relationships with N2 O emission responses to land use conversion and reversion. And the importance of driving factors displayed that CO2 , CH4 , and N2 O response to land use conversion and reversion was easily affected by NH4 + and soil moisture, mean annual temperature and NO3 - , total nitrogen and mean annual temperature, respectively. This study would provide enlightenments for scientific land management and reduction of GHG emissions.

Comprehensive efficiency evaluation of wastewater treatment plants in northeast Qinghai-Tibet Plateau using slack-based data envelopment analysis.

Comprehensive efficiency analysis of wastewater treatment plants (WWPTs) in the alpine region with harsh environment and poor techniques as well as managing experience could provide targeted and effective improvement evidences for local wastewater treatment industry and help to improve the water quality of downstream reaches. In this paper, slack-based data envelopment analysis (SBM-DEA) was adopted to assess the operating efficiencies of WWPTs in northeast Qinghai-Tibet Plateau (QTP). Results showed that the average efficiency score for all WWPTs was 0.608, and 32.5% of WWPTs were efficient. Some WWPTs had large improvement potentials in operating costs and pollutant removal rates. Lowering expenditures and promoting facility construction for WWPTs to overcome the climate difficulties and improve management level was necessary according to their improvement potentials. In addition, the relative importance of the quantitative influential factors to efficiencies scores calculated by random forest regression (RFR) indicated that design capacity and temperature were important quantitative factors affecting the performance of WWPTs. Furthermore, geographical location and design capacity also had significant influence on the comprehensive efficiency of WWPTs verified by Kruskal-Wallis test. Our results highlight the importance of facilities upgrading, scientific management for WWPTs. And the relative improvement suggestions on overcoming the high and cold environment should also be considered for the efficient operations of WWTPs as well as the protection the aquatic environment.

Research on Expansion Characteristics of Aquaculture Ponds and Variations in Ecosystem Service Value from the Perspective of Protecting Cultivated Lands: A Case Study of Liyang City, China.

In the context of global food insecurity, a large amount of cultivated land in China has been occupied by aquaculture ponds, leading to a series of variations in the ecological environment. The Chinese government pays close attention to the problem. In order to achieve sustainable development and ensure the safety of China's cultivated land, the paper uses Liyang City as an example to discuss the spatial characteristics of the expansion of aquaculture ponds through occupying cultivated lands and analyzes the variations in ecosystem service value and cultivated land function. The conclusions are as follows: (1) 2073.24 hectares of cultivated lands were occupied for expanding aquaculture ponds in Liyang from 2009 to 2019, and there was a small number of new aquaculture ponds in the ecological protection area, which shows that the aquaculture ponds in Liyang City are at the stage of disorderly expansion; (2) the total value of ecosystem services increased by 1.43%; supply and support services values decreased, but the increase in regulation and cultural services values was sufficient to more than compensate for the mentioned losses; and (3) the expansion of aquaculture ponds leads to a decrease in the carbon storage of cultivated land, which in turn has negative impacts such as an increase in atmospheric carbon concentration.

Spatial temporal patterns and driving factors of industrial pollution and structures in the Yangtze River Economic Belt.

The conflict between industrial development and environmental pollution is global. This study quantitatively analyzes the temporal and spatial changes, spatial effects and determinants of industrial pollution discharge in the Yangtze River Economic Belt through two main indicators: wastewater and SO2. Analyze the spatial coupling relationship between industrial agglomeration and pollution emission and the characteristics of industrial structure in different regions. The analysis shows that industrial emissions in the Yangtze River Economic Belt first increased and then decreased during the period 2003-2019. Industrial pollution spread from large to small and medium cities and shifted from downstream to upstream. Moreover, a positive correlation exists between industrial pollution discharge and per capita GDP, secondary industry proportion, population density, and energy use. Meanwhile, scientific and technological progress and environmental regulations are associated with industrial pollution reduction. Since the Yangtze River Economic Belt was still in the industrialization stage and had not yet reached a turning point on the Environmental Kuznets Curve. The "pollution refuge" phenomenon was evident in the Belt, where underdeveloped areas in the central and western regions accommodated portions of highly polluting industries from the eastern areas through "regional competition" and "policy depression." The industrial agglomeration and pollution antagonistic zones were dominated by polluting industries; environmental risks were greatest in these areas. The upstream and downstream of the YREB play the negative and positive environmental externalities of industrial agglomeration, respectively. Thus, differential control measures should be formulated according to different regions, industrial pollutants, and polluting industries to improve environmental quality.

Antibacterial Effect of Phenolic Acids Derived from Rice Straw and in Combination with Antibiotics Against Escherichia coli.

Many studies have demonstrated that natural plant extracts have inhibitory effects on microorganisms. The purpose of this study was to investigate the inhibitory effect of phenolic acids from rice straw (PAs) on Escherichia coli and their synergistic effect in combination with antibiotics. PAs can inhibit the growth of E. coli effectively by inducing the formation of H2O2; PA-treated cells had a tenfold greater intracellular H2O2 concentration than the control group. The synergistic effect caused by the interaction of PAs and antibiotics on inhibiting the growth of E. coli was significant. This effect may be caused by a PA-induced change in the permeability of E. coli cell membrane. The treatment with PAs made the extracellular K+ concentration reached 15 mg/L within 30 min, while the K+ concentration in the control group was very low and did not change significantly over time. Similarly to the extracellular K+, the extracellular protein concentration exceeded 150 mg/L in the PA treatment group, while it remained very low in the control group. Due to the increased cell permeability, more antibiotics can enter the cell. Hence, this study may provide a novel method of improving the safe use of antibiotics.

Analysis of spatio-temporal distribution characteristics and socioeconomic drivers of urban air quality in China.

Having high spatio-temporal resolution data of pollutants is critical to understand environmental pollution patterns and their mechanisms. Our research employs the hourly average concentration data on the air quality index (AQI) and its six component pollutants (PM2.5, PM10, SO2, NO2, CO, and O3) in 336 Chinese cities from 2014 to 2019. We analyze annual, seasonal, monthly, hourly, and spatial variations of different air pollutants and their socioeconomic factors. The results are as follows. (1) Air pollutants' concentration in Chinese cities decreased year by year during 2014-2019. Among the primary pollutants, PM2.5 dominated pollution days, accounting for 38.46%, followed by PM10. Monthly concentration curves of AQI, PM2.5, NO2, SO2, and CO showed a U-shaped trend from January to December, while that of O3 presented an inverted U-shaped unimodal pattern. Regarding daily variation, urban air quality tended to be worse around sunrise compared with sunset. (2) Chinese cities' air quality decreased from north to south and from inland to coastal areas. Recently, air quality has improved, and polluted areas have shrunk. The six pollutant types showed different spatial agglomeration characteristics. (3) Industrial pollution emissions were the main source of urban air pollutants. Energy-intensive industries, dominated by coal combustion, had the greatest impact on SO2 concentration. A "pollution shelter" was established in China because foreign investment introduced more pollution-intensive industries. Thus, China has crossed the Kuznets U-curve inflection point. In addition, population agglomeration contributed the most to PM2.5 concentration, increasing the PM2.5 exposure risk and causing disease, and vehicle exhaust aggravated the pollution of NO2 and CO. The higher China's per capita gross domestic product, the more significant the effect of economic development is on reducing pollutant concentration.

Utilization of straw-based phenolic acids as a biofugicide for a green agricultural production.

Phenolic compounds inhibit phytopathogenic fungal infections effectively. In this study, the antifungal effects of rice straw-derived phenolic acids (PAs) against Fusarium oxysporum were investigated. PAs can inhibit hyphal growth and spore germination, and p-coumaric acid (CA) is the main antifungal substance in PAs. PAs could induce the formation of hydrogen peroxide and increase the relative conductivity and extracellular K+ concentration. Observations using Scanning Electron Microscopy, Laser Scanning Confocal Microscopy and Transmission Electron Microscopy revealed that PAs could damage membrane permeability, which caused cytoplasm leakage. This phenomenon was verified by conductivity and the release of extracellular K+. The chlorophyll fluorescence maps of tomato leaves suggested that F. oxysporum damaged the tomato' photosynthetic system and that PAs reduced the area infected, thereby alleviating the damage. Moreover, PAs could decrease the disease incidence of tomato fruit. The results confirmed the feasibility of using PAs as a biofungicide and provide a way to increase the value of rice straw.

Spatial distribution and source analysis of heavy metals in soils influenced by industrial enterprise distribution: Case study in Jiangsu Province.

Heavy metal pollution is frequent in China and has received increasing attention globally. This study investigated the influence of Chinese industrialization and urbanization on soil environmental quality. Soil samples from Jiangsu Province were collected, the Cd, Pb, Cr, Cu, Zn, Hg, and As contents were measured, and their spatial variability structure, spatial distribution pattern, and pollution degree were analyzed. The mean values of Hg, Cd, Pb, Cr, Cu, and As were all higher than the background values in Jiangsu Province. Cr and As levels represented moderate pollution, Cu, Zn, Cd, and Pb represented mild pollution, Cr and As represented slight pollution, and Hg was not a pollutant. Spatial distribution patterns were both zonal and concentrated in nature. High concentrations of heavy metals were distributed in developed cities and industrial parks along the Yangtze River. Soil heavy metal pollution showed a decreasing trend from south to north, consistent with the economic gradient. Industrialization had the greatest influence on the spatial heterogeneity of heavy metal pollution. Cr, Cu, Zn, and As were affected by both natural and anthropogenic sources, while Cd and Pb were mainly affected by the latter. Hg was mainly derived from industrial activities such as petrochemical production. There was spatial consistency between industrial enterprise distribution and soil heavy metal pollution with a tendency toward composite pollution accumulated by multiple elements in the soil surrounding industries.

Simultaneous production of cellulase and ferulic acid esterase by Penicillium decumbens with rice straw as the sole carbon source.

As well as cellulose and hemicelluloses, rice straw contains phenolic acids. The simultaneous production of monosaccharides and phenolic acids could improve the value of rice straw. In this study, it was confirmed that Penicillium decumbens produces more ferulic acid esterase (FAE) than other cellulase-producing fungi. Cellulose, destarched wheat bran (DSWB), and rice straw were used as carbon sources. Little phenolic acid was released by cellulose- and DSWB-based enzymes during the saccharification of rice straw, whereas rice straw was a favorable carbon source for the simultaneous production of cellulase and FAE. High-performance liquid chromatography showed that during enzyme production, phenolic acids were released from rice straw, and ball-milling affected this release of phenolic acids. Small amounts of phenolic acids induced FAE production. Although the enzymes produced with rice straw showed lower FAE activity than those produced with DSWB, phenolic acids were produced efficiently during the saccharification of rice straw in response to the synergistic effects of cellulase and FAE. Therefore, we suggest that the production of enzymes by P. decumbens on rice straw as the sole carbon source will allow the production of more valuable products from rice straw, making the utilization of rice straw more economic.

Spatial-Temporal Evolution of PM2.5 Concentration and its Socioeconomic Influence Factors in Chinese Cities in 2014⁻2017.

PM2.5 is a main source of China's frequent air pollution. Using real-time monitoring of PM2.5 data in 338 Chinese cities during 2014⁻2017, this study employed multi-temporal and multi-spatial scale statistical analysis to reveal the temporal and spatial characteristics of PM2.5 patterns and a spatial econometric model to quantify the socio-economic driving factors of PM2.5 concentration changes. The results are as follows: (1) The annual average value of PM2.5 concentration decreased year by year and the monthly average showed a U-shaped curve from January to December. The daily mean value of PM2.5 concentration had the characteristics of pulse-type fluctuation and the hourly variation presented a bimodal curve. (2) During 2014⁻2017, the overall PM2.5 pollution reduced significantly, but that of more than two-thirds of cities still exceeded the standard value (35 µg/m³) regulated by Chinese government. PM2.5 pollution patterns showed high values in central and eastern Chinese cities and low values in peripheral areas, with the distinction evident along the same line that delineates China's uneven population distribution. (3) Population agglomeration, industrial development, foreign investment, transportation, and pollution emissions contributed to the increase of PM2.5 concentration. Urban population density contributed most significantly while economic development and technological progress reduced PM2.5 concentration. The results also suggest that China in general remains a "pollution shelter" for foreign-funded enterprises.

The effect of hydroxy safflower yellow A on coronary heart disease through Bcl-2/Bax and PPAR-γ.

The aim of the present study was to investigate the effect of hydroxy safflower yellow A (HSYA) on coronary heart disease through assessing the expression of B-cell lymphoma 2 (Bcl-2)/Bcl-2-like protein 4 (Bax) and peroxisome proliferator-activated receptor (PPAR)-γ. Coronary heart disease was induced in male Bama miniature swines via thoracoscope to serve as an animal model. Coronary heart disease swine were lavaged with 20 or 40 mg/kg HSYA. The mRNA levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1ß, IL-6, IL-10, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were detected using reverse transcription-quantitative polymerase chain reaction. The protein expression of Bcl-2, Bax, PPAR-γ, phosphorylation of Janus kinase (JAK)2 and phosphorylation of signal transducer and activator of transcription (STAT)3 were detected using western blot analysis. Treatment with HSYA significantly suppressed the mRNA levels of IL-1ß (P<0.01), IL-6 (P<0.01), TNF-α (P<0.01), COX-2 (P<0.01) and iNOS (P<0.01), and significantly increased IL-10 mRNA level in the coronary heart disease model (P<0.01). Furthermore, HSYA treatment significantly decreased the Bcl-2/Bax ratio (P<0.01) in the coronary heart disease model group, and enhanced the phosphorylation of JAK2/STAT3 pathway (P<0.01). However, HSYA had no significant effect on the expression of PPAR-γ protein. The results of the present study suggest that HSYA is able to weaken coronary heart disease via inflammation, Bcl-2/Bax and the PPAR-γ signaling pathway.

Environmental Iodine Content, Female Sex and Age Are Associated with New-Onset Amiodarone-Induced Hypothyroidism: A Systematic Review and Meta-Analysis of Adverse Reactions of Amiodarone on the Thyroid.

OBJECTIVES: To investigate the incidence of new-onset amiodarone-induced hypothyroidism (AIH) and the associated risk factors. METHODS: We performed a systematic search in MEDLINE, Embase, the Cochrane Library and the Chinese database from 1995 to 2015. Studies that investigated amiodarone-related adverse reactions on the thyroid were included. A random-effect model was used for the meta-analysis to investigate the incidence rate of AIH and associated risk factors. RESULTS: We identified 465 studies, of which data from 9 studies were included, comprising 1,972 patients. The incidence of AIH was 14.0% (95% confidence interval, CI, 8.7-21.7%) as a whole; it was higher in areas with a high than a low iodine content in the environment (20.3 vs. 8.7%, p < 0.001); subgroup analysis showed that AIH occurred in 19.2% (95% CI 10.2-33.1%) of women and 13.3% (95% CI 7.9-21.7%) of men (p < 0.001). Meta-regression analysis indicated a positive correlation with the mean age and percentage of women. CONCLUSIONS: The occurrence of AIH is a relatively frequent complication of amiodarone, and older women are more likely to develop AIH, especially in areas with a high iodine content in the environment, and restriction of total exposure to iodine might decrease the incidence of AIH.

Cholesterol consumption and risk of endometrial cancer: a systematic review and dose-response meta-analysis of observational studies.

In vivo and in vitro studies have indicated the link of cholesterol consumption and endometrial cancer risk, however, previous observational studies have yielded inconsistent results. Additionally, a previous meta-analysis published in 2007 found limited evidence of aforementioned association. Therefore, we performed the dose-response meta-analysis to address this concern. Studies were identified using the PubMed, EMBASE and Web of Science databases from the database inception to the end of June 2015 as well as by examining the references of retrieved articles. Two authors independently performed the eligibility evaluation and data extraction. The summary risk estimates and 95% confidence intervals (CIs) were summarized by the random-effects models. One cohort and nine case-control studies were included in the dose-response analyses. Risk of endometrial cancer increased by 6% for 100 mg/day increment in the dietary consumption of cholesterol (Odds ratio (OR) = 1.06; 95% CI = 1.00-1.12), with significant heterogeneity (I2 = 64.2, P = 0.003). When stratified by study design, the result was significant in case-control studies (OR = 1.07; 95% CI = 1.01-1.13). Additionally, although the direction of the associations were consistent in the subgroup analyses stratified by study characteristics and adjustment for potential confounders, not all of them showed statistical significance. In summary, findings of the present dose-response meta-analysis partly support the positive association between dietary cholesterol consumption and risk of endometrial cancer. Since only one cohort study was included, more prospective studies and pooled analysis of observational studies are warranted to confirm our findings in the future.

History of diabetes mellitus is associated with elevated cardiac troponin I levels in patients with chest pain but no coronary heart disease.

BACKGROUND: The factors and the mechanism contributing to an increase in cardiac troponin I (cTnI) in patients with chest pain, at least one cardiovascular risk factor, and no evidence of coronary heart disease remains elusive. METHODS: Excluding patients with acute coronary syndrome and chronic myocardial isch-emia, we selected 362 consecutive patients with normal coronary angiography or computed tomography coronary angiography results or lesions causing < 50% stenosis in any of the coronary arteries from January 2012 to June 2015. Using a cut-off value of 0.01 ng/mL, patients with cTnI levels ≥ 0.01 ng/mL (164 patients) were compared with those with cTnI levels < 0.01 ng/mL. Logistic regression analysis was used to evaluate associations between elevated cTnI and patient characteristics. RESULTS: Other than history of diabetes mellitus (DM) (18.90% vs. 8.08%, p = 0.002), the characteristics of the patients with and without elevated cTnI levels were similar. History of DM predicted elevation of cTnI level (OR 3.34, 95% CI 1.55-7.20, p = 0.002) in logistic regression analysis. CONCLUSIONS: In total, 45.30% of patients with chest pain had elevated cTnI levels with a mean level of 0.07 ± 0.10 ng/mL. History of DM rather than blood glucose level itself was associated with elevated cTnI levels, whereas female gender was protective against increases in cTnI levels.

Dietary fatty acids intake and endometrial cancer risk: a dose-response meta-analysis of epidemiological studies.

Epidemiological studies have provided controversial evidence of the association between dietary fatty acids intake and endometrial cancer risk. The continuous update project of World Cancer Research Fund failed to focus on this issue. To address this inconsistency, we conducted this dose-response meta-analysis based on epidemiological studies published up to the end of June 2015 identified from PubMed, EMBASE and Web of Science. Two authors independently performed the eligibility evaluation and data extraction. Random-effects models were used to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). Fourteen epidemiological studies (4 cohort and 10 case-control studies) were included in this dose-response meta-analysis. The summary RR for an intake increment of 10g/day was 1.02 (95% CI = 0.97-1.08; I2 = 66.0%) for saturated fatty acids, 0.98 (95% CI = 0.96-1.001; I2 = 0%) for monounsaturated fatty acids, and 1.00 (95% CI = 0.95-1.06; I2 = 0%) for polyunsaturated fatty acids intake. Non-significant results were observed in the majority of subgroup analyses stratified by study characteristics and adjustment for potential confounders in analyses of aforementioned associations. In conclusion, results from this dose-response meta-analysis provided limited evidence that dietary saturated, monounsaturated, and polyunsaturated fatty acids consumption was associated with endometrial cancer risk. Further studies, especial prospective designed or pooled studies are warranted to confirm our findings.

Fish consumption and risk of myeloma: a meta-analysis of epidemiological studies.

PURPOSE: The relationship between fish consumption and multiple myeloma (MM) risk has not been consistent across epidemiological studies. We quantitatively assessed the aforementioned association through a systematic review and meta-analysis. METHODS: PubMed was searched through the end of March 2015 for eligible studies. Fixed or random effects models were used to pool risk estimates. Five case-control studies that involved 1,366 cases and 8,259 controls were identified. Three studies had high methodological quality, and two studies had low quality based on the Newcastle-Ottawa Quality Assessment Scale. RESULTS: After pooling all risk estimates, a significant inverse association was found between the highest category versus lowest category of fish consumption and MM risk (relative risk = 0.65, 95% confidence interval = 0.46-0.91), with relatively high heterogeneity (I(2) = 55.6%). No evidence of publication bias was detected. The inverse association persisted in all subgroups according to study quality, type, location, and whether there were adjustments for confounders, although statistical significance was not detected in all strata. The dose-response analysis suggested a nonlinear dose-response relationship for the association, with the lowest risk linked to fish consumption once per week. CONCLUSION: This meta-analysis suggests that the highest versus lowest category of fish consumption is inversely associated with MM risk. Furthermore, a nonlinear dose-response relationship was suggested for the association. Because this evidence is based on a small number of retrospective studies with mixed quality and because high heterogeneity was detected, further prospective studies are warranted to validate our findings and better characterize the relationship.